6q Probe (6q22)
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ROS1 Gene Break Apart Rearrangement Detection Probe
1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour.
2.Accuracy: Less no◆n-specific background staining (dyeing). Increase difficult samples detection rate.
3.Reproducibility: Different laboratories test results are highly reproducible.
ROS1 gene break-apart rearrangement probe uses orange-red dye to mark the ROS1 gene 5' end region and green dye to mark ROS1 gene 3' end region. The ROS1 gene break-apart rearrangement can detect all ROS1 gene rearrangements, avoiding the missed diagnosis caused by a single fusion gene.
ROS1 gene break-apart rearrangement occurs mostly in young, non-smoking lung adenocarcinoma patients. ROS1 rearrangements are different from other mutations such as EGFR, KRAS and ALK. The positive rate of ROS1 rearrangement is about 1.5%, and ROS1 rearrangement positive adenocarcinoma is poorly differentiated. ROS1 break-apart rearrangement positive patients are sensitive to XALKORI (Crizotinib) drugs.
Rimkunas VM, et al. (2012) Clin Cancer Res 18: 4449-57.
Suehara Y, et al. (2012) Clin Cancer Res 18: 6599-608.
Takeuchi K, et al. (2012) Nat Med 18: 378-81.